Figure 2.

Correlation between skin AF and HbA_1c at baseline or past HbA_1c level. A: There were weakly positive correlations between skin AF and HbA_1c at baseline (R = 0.27; P < 0.0001). B–F: The relationships between skin AF and past HbA_1c levels. To determine the effects of past glycemic control and its duration on current skin AF, the correlation between HbA_1c AUC values and skin AF were determined over the past 20 years. HbA_1c AUC from baseline to 15 years ago was significantly correlated with skin AF (B) over the past 3 years (n = 200): R = 0.29, P < 0.0001; (C) over the past 5 years (n = 179): R = 0.35, P < 0.0001; (D) over the past 10 years (n = 110): R = 0.36, P < 0.0001; (E) over the past 15 years (n = 58): R = 0.55, P < 0.0001; and (F) over the past 20 years (n = 28): R = 0.22, P = 0.13. (A high-quality color representation of this figure is available in the online issue.)