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. 2013 Aug;94(2):377–383. doi: 10.1189/jlb.0912441

Figure 3. Tregitopes have a low or no immunogenicity in BALB/c mice.

Figure 3.

BALB/c mice were treated with IFA-emulsified Tregitopes (mixture of mTregitope167 and mTregitope289) or OVA323–339 peptide. Two weeks later, T cell proliferation assay was performed (same as in Fig. 2). Cells (5×105) were seeded/well in 96-well plates in the presence of mTregitope167/mTregitope289 or OVA323–339 peptide. Forty-eight hours later, cells were pulsed with 1 μg/ml [3H] thymidine and cultured for another 16–20 h. Data represent mean Δcpm ± se for four animals. This is a representative of two independent experiments.