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. 2013 Aug;27(8):3078–3089. doi: 10.1096/fj.13-228551

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Figure 7. — Dipyridamole relies on alveolar epithelial Adora2b. WT (BL6C57) or Ent2^−/− mice were exposed to ventilator induced lung injury (VILI; pressure-controlled mechanical ventilation at an inspiratory pressure of 45 mbar with an inspired oxygen concentration of 100% and exposure time of 180 min). A) IL-6 levels in WT or Ent2^−/− mice were evaluated in lung tissue homogenates using a mouse ELISA. Results are means ± sd (n=6). B, C) WT (B) or Adora2b^f/f Spc-Cre (C) mice were pretreated with dipyridamole before the onset of VILI, and IL-6 levels were evaluated in lung tissue homogenates using a mouse ELISA. Results are means ± sd (n=6). Note abolished anti-inflammatory effect of dipyridamole during VILI in mice lacking Adora2b on lung epithelial cells only.