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Delayed onset of humoral autoimmunity in Sle1b.OPN−/− mice. Anti-chromatin IgG (A) and total IgG (B) levels in the serum of B6, Sle1b, and Sle1b.OPN−/− mice were determined with ELISA. EU, ELISA unit. Age 6–7 wk: B6, n = 4; Sle1b, n = 9; Sle1b.OPN−/−, n = 4. Age 9–12 wk: B6, n = 6; Sle1b, n = 6; Sle1b.OPN−/−, n = 4. Age 14–19 wk: B6, n = 3; Sle1b, n = 4; Sle1b.OPN−/−, n = 4.
