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. 2013 Jan;1832(1):160–173. doi: 10.1016/j.bbadis.2012.10.011

Fig. 1.

Fig. 1

The WASH and retromer complexes. The WASH complex comprises the core proteins KIAA1033, strumpellin, Wash1 and FAM21. Wash1, FAM21 and strumpellin interact directly with KIAA1033, while the association between the WASH and retromer complexes occurs via the tail domain of FAM21. FKBP15, a protein of unknown function, interacts with both retromer and the FAM21 tail. Retromer consists of a core complex of VPS26, 29 and 35, with an associated sorting nexin dimer comprising a combination of SNXs 1, 2, 5 and 6. SNX27 has been reported as an additional interactor of the WASH complex. Interactions between the sorting nexins and the WASH and retromer complexes are indicated by arrows.