Fig. 7.

Strumpellin mutation does not induce endosomal tubulation. HeLa cells were transfected with strumpellin-myc (A) or strumpellin-myc-L619F (B), then labelled with SNX1. In (B) the arrowheads indicate a tubular structure. (C) The mean number of SNX1 tubules per cell was counted in mock transfected cells (Mock) and in cells transfected with wild type strumpellin-myc (Wild type) or with the disease mutants strumpellin-myc V626F (V626F), strumpellin-myc L619F (L619F) and strumpellin-myc N471D (N471D). Error bars represent S.E.M., n = 3 experiments.