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. 2013 Jun 5;33(23):9743–9751. doi: 10.1523/JNEUROSCI.0499-13.2013

Figure 5.

Figure 5.

The ACC/PLC is necessary for chocolate-induced cataplexy. A, Typical injection site showing GluCl expression in the ACC and PLC. Scale bar, 500 μm. B, Experimental design to test the effect of reversible silencing of the ACC/PLC using IVM on cataplexy. C, Effect of IVM on cataplexy bouts, wakefulness, and chocolate intake of orexin KO mice injected with AAV-GluCl (n = 5, top) or AAV-GFP (controls, n = 5, bottom). In mice injected with AAV-GluCl, IVM reversibly reduces the number of cataplexy bouts with chocolate, but has no effect in the baseline condition. *p < 0.05; **p < 0.01. D, Superimposed GluCl injection sites in the ACC/PLC (n = 5). E, Mice with more GluCl expression in the ACC/PLC have greater reductions in cataplexy. This correlation was not apparent in the ILC (n = 17).