Figure 3.

Plots consist of an average accumulation of platelets in the model over a 4-min time span. The experimental curve corresponds to the equation: $J_{\left(<6790s^{-1}\right)}=1.7{\dot{\gamma }}^{0.30}-3.0,J_{\left(>6790s^{-1}\right)}=34-1.1{\dot{\gamma }}^{0.28}\mu {\text{m}}^3/\mu {\text{m}}^2-\min$. (A) Platelet flux to the wall versus shear rates for different model transport conditions compared to experimental thrombus growth rates for an 84% stenosis with a flow rate of 0.25 mL/min and a kinetic binding rate of 10⁻³ m/s, which effectively acts as infinite sink for shear rates <6000 s⁻¹. (i) Platelet flux from thermal motion. (ii) Platelet flux from enhanced diffusivity (ED) only. (iii) Platelet flux with ED and RBC skewing. (iv) Platelet flux from the Leveque approximation. (B) Modeled thrombus growth rates relative to shear under the conditions of panel A, but with different kinetic binding rates: (i) k_t = 10⁻³ m/s, (ii) k_t = 10⁻⁴ m/s, and (iii) k_t = 10⁻⁵ m/s. (iv) The Leveque model is also plotted with a kinetic binding rate, k_t = 10⁻⁴ m/s, for comparison. (C) Modeled thrombus volume versus time for two conditions compared to an average of experimental thrombus growth with a flow rate based of 0.25ml/min and an initial 84% stenosis. (i) k_t = 10⁻⁴ m/s. (ii) k_t = 10⁻⁴ m/s in addition to a lag time for platelet activation under shear as described by Eq. 12. Note that the lag time is added based on the average lag time as a function of shear rate given in Bark et al. (38).