Table 1.
Main characteristics of inherited endocrine tumors and their sporadic endocrine tumor counterparts, and the differential management of these conditions.
| IETs | SETs counterparts | |
| Age at diagnosis | low | high |
| Associated tumors | + | - |
| Germline mutation | + | - |
| Inheritance | A.D. | - |
| Multicentric tumors | + | - |
| Bilateral tumors | + | -/rare |
| Pre-malignant stage | + | - |
| Aggressiveness | > | < |
| Specific tumor locations | + | + |
| Mixed tumors types | + | -/rare |
| Genetic heterogeneity | + | - |
| Clinical heterogeneity | + | - |
| Founder effect | + | - |
| Two-hit model of tumorigenesis | + | - |
| Early genetic diagnosis | + | - |
| Genetic counseling | + | - |
| Pre-symptomatic diagnosis | + | - |