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Immunohistochemical analysis of bronchial biopsies from smokers (including 31 dysplastic and 67 hyperplastic/metaplastic sites). A, photomicrographs showing representative immunohistochemical staining for P-Akt (T308) and P-ERK (T202/Y204) in normal lung (top) and dysplastic lesions (bottom). B, percentage of lesions positive for P-Akt (T308) and P-ERK (T202/Y204). C, association between activated Akt and ERK in hyperplastic/metaplastic and dysplastic lesions.
