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Transcriptional regulation by FOXO1 and Sirt1 in response to nitric oxide. Nitric oxide stimulates FOXO1 nuclear localization. When Sirt1 is more active, FOXO1 is deacetylated and directs the expression of protective factors such as the DNA repair gene GADD45α. When Sirt1 is less active, FOXO1 is acetylated (FOXO1-AC) and directs the expression of proapoptotic factors such as PUMA.
