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. Author manuscript; available in PMC: 2013 Jul 18.
Published in final edited form as: Nanotoxicology. 2010 Dec 22;5(4):592–605. doi: 10.3109/17435390.2010.541292

Figure 7. Effect of nanoART on the BBB integrity.

Figure 7

Confluent HBMEC were exposed to monocytes (A, B) and MDM (E, F) loaded with H1008 and H2014 (0.5 mM), or exposed to CM from monocytes (C, D) and MDM (G, H) loaded with H1008 and H2014 (0.5 mM), and TEER measured in real-time as described in the Method section. Monocytes or CM from monocytes carrying H1008 and H2014 did not alter TEER (A-D). MDM carrying H1008 or H2014 did not alter TEER (E, F). CM from MDM carrying H1008 reduced the TEER by 5% and CM from MDM-loaded with H2014 decreased TEER by 12% (**P<0.01). Similar results were observed with other nanoformulations and lower concentrations (0.1 mM) did not alter TEER. Data shown are representative of 2 independent experiments. Lysophosphatidic acid was used as a positive control for lowering TEER.