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. Author manuscript; available in PMC: 2013 Jul 18.
Published in final edited form as: J Nat Prod. 2009 Jan;72(1):92–98. doi: 10.1021/np800653z

Table 4.

Antiparasitic Activities of P. glandulosa Extracts and Compound 1–8

Extract/compound P. falciparum (ng/mL) VERO L. donovani
D6a W2b (ng/mL) (μg/mL)
IC50 SIc IC50 SIc IC50 IC50 IC90
P. glandulosa (EtOH extr.) 13000 >3.7 10000 >4.8 NC 44 90
P. glandulosa (Alkaloid Fr.) 420 64 630 43 27000 18 35
1 39 >610 95 >250 >23800 0.7 1.9
2 120 47 230 24 5600 0.65 2.0
3 83 22 150 12 1800 0.26 1.2
4 42 >567 120 >198 >23800 0.8 2.5
5 220 23 380 13 5000 0.75 2.4
6 430 >11.1 270 >17.6 NCd 2.8 8.0
7 600 >7.9 560 >8.5 NCd 3.1 7.0
8 380 >12.5 290 >16.4 NCd 0.7 1.2
Chloroquine 17 140 NC NT NT
Artemisinin 16 17 NC NT NT
Pentamidine NT NT NT 0.5 2.0
Amphotericin B NT NT NT 0.1 0.4
a

Chloroquine-sensitive clone.

b

Chloroquine-resistant clone.

c

Selectivity index = IC50 VERO cells/IC50 P. falciparum.

d

NC = Not cytotoxic (up to the maximum dose tested; 4760 ng/mL for pure compounds and 47600 ng/mL for crude extracts). NT= Not tested.