Figure 3.

Interactions between aromatic rings as well as atoms and aromatic rings in the dimeric small molecule complex in the p53 pocket of MDM2 (PDB: 3VBG). The inhibitor complex leads to the dimerization of MDM2 and MDMX proteins, eventually causing cell cycle arrest and apoptosis. Aromatic–ring interactions are displayed using a cyan dashed line, halogen-pi interactions are shown as dark blue dashed line, carbon-pi in orange and undefined atom-ring interactions simply in grey. Only interactions within 4.0 Å are shown.