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. Author manuscript; available in PMC: 2014 Jul 1.
Published in final edited form as: J Neuropathol Exp Neurol. 2013 Jul;72(7):708–715. doi: 10.1097/NEN.0b013e31829a25b9

Figure 2.

Figure 2

Amyloid-β (Aβ) immunohistochemistry demonstrating cerebral amyloid angiopathy (CAA) severity scale in parenchymal blood vessels. (A) CAA in a narrow artery with a focal aggregation of Ab immunopositivity. A section in which this pattern predominates was designated “Stage 1” CAA. (B) A case in which there are many parenchymal Ab plaques but there is only scattered CAA of intermediate severity (arrow), which would be designated “Stage 2” CAA. (C) A section with minimal parenchymal Ab plaques but relatively strong uniform Ab immunostaining of vessels (arrows); this would still be “Stage 3” CAA. (D) Many cases with “Stage 3” CAA showed strong Ab immunopositivity outlining small blood vessels, including capillaries (arrows). Scale bars: A, C, = 200 mm; B, 50 mm; D, 40 mm.

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