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. Author manuscript; available in PMC: 2014 Mar 4.
Published in final edited form as: Mol Pharm. 2013 Jan 25;10(3):988–998. doi: 10.1021/mp300436c

Figure 3.

Figure 3

Stability of radiolabeled G6.5-COOH dendrimers evaluated under various in-situ conditions as analyzed by size exclusion chromatography. A) Stability of the compound in mice intestinal secretions indicated minimal release of small molecular weight impurities over time (1h, 4h and 12h). B) Stability of radiolabeled G6.5-COOH after 2h of exposure in the rat in-situ loop perfusion model also indicated minimal release. C) Stability of the radiolabeled compound in mice serum over 24h showed intact large molecular weight radiolabeled dendrimers. Na125I was tested as a control small molecule. Tables indicate the % area under the curve (AUC) for the peaks.