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. 2013 Apr 28;17(2):345–352. doi: 10.1093/icvts/ivt178

Table 1:

Characteristics and details of the included studies

Author Design Patient population AKI definition Statin users (n) Non-statin users (n) AKI
RRT
Mortality
Downs and Black Score
S (n) NS (n) Adjusted odds (CI) S (n) NS (n) Adjusted odds (CI) S (n) NS (n) Adjusted odds (CI)
Ali and Buth [8] RC C, V, C + V NR 3555 1914 NR NR NR NR NR NR 451 373 0.9 (0.6–1.2) 20
Allou et al. [9] RC C 50% increase from baseline 222 208 22 29 NR NR NR NR NR NR 0.52 (0.25–1.11) 18
Argalious et al. [5] RC C V RIFLE 6152 4487 819 467 0.97 (0.84–1.12) 108 74 0.8 (0.55–1.18) 105 77 0.803 (0.56–1.16) 19
Billings et al. [10] RC C AKIN 174 150 39 29 1.24 (0.66–2.32) NR NR NR NR NR NR 21
Bolesta et al. [11] RC C AKIN 356 207 125 54 1.36 (0.904–2.05) NR NR NR NR NR NR 19
Borger et al. [12] RC C, V and C + V Increased Cr or RRT 4216 5538 NR NR NR 451 454 NR 316 366 0.89 (0.75–1.06) 18
Clark et al. [13] RC C, V, C + V NR 1044 2785 NR NR NR NR NR NR 26 155 0.55 (0.32–0.93) 17
Coleman et al. [14] RC C, V, C + V NR 1248 686 NR NR NR NR NR NR 53 42 0.85 (0.51–1.43) 17
Fedoruk et al. [15] RC V Two times increase from baseline or RRT 203 244 8 14 2.17 (0.824–5.698) NR NR NR 7 13 2.7 (0.81–9.05) 19
Huffmyer et al. [4] RC C RRT or more than 50% decrease in eGFR 1557 1203 436 331 1.012 (0.893–1.145) 30 43 0.542 (0.379–0.774) 31 51 0.572 (0.42–0.779) 17
Mithani et al. [16] RC C, V, C + V AKIN 1434 670 322 173 0.79 (0.59–1.06) 20 7 NR NR NR NR 21
Powel et al. [17] RC C NR 2334 2405 NR NR NR NR NR NR 32 53 0.83 (0.50–1.37) 17
Subramaniam et al. [18] RC C New onset renal failure requiring dialysis 1835 652 8 8 1 (0.37–2.68) 8 8 1 (0.37–2.68) 5 8 0.62 (0.20–1.91) 17
Tabata et al. [19] RC C RRT, two times increase in S Cr and S Cr of >2 mg/dl 1039 763 NR NR 0.54 (0.3–0.99) NR NR NR NR NR NR 18
Virani et al. [20] RC V NR 255 570 NR NR NR NR NR NR 9 31 0.89 (0.38–2.03) 18
Virani et al. [21] RC C, V, C + V Any increase Sr Cr, ATN, AIN or Anuria 1675 13 26 42 46 0.6 (0.38–0.95) NR NR 0.71 (0.41–1.24) NR NR NR 17
Pan et al. [22] RC C RRT, at least 2 mg/dl, 0.7 mg/dl rise or RF on autopsy 943 720 59 39 NR NR NR NR 17 27 0.53 (0.28–0.99) 18

AKIN: acute kidney injury network; ATN: acute tubular necrosis; AIN: acute interstitial nephritis; RC: retrospective cohort; C: CABG; V: isolated valve surgery; Cr: creatinine; C + V: any cardiac surgery (including CABG, valve or combined); RRT: renal replacement therapy; RIFLE: risk injury failure loss and end stage renal disease; NR: not reported; S: preoperative statin treatment group; NS: no preoperative statin group; eGFR: estimated glomerular filtration rate; Sr: serum.