Table 2.
Prevalences of EH polymorphisms in Caucasian and African American controls at New York
| Region | Codon | Sequence change | Amino acid change | Allelic frequencies | |
|---|---|---|---|---|---|
| Caucasians | African Americans | ||||
| Exon 2 | 431 | G > C | Arg > Thr | 0.01 (1/100)2 | 0.01 (2/168) |
| Exon 3 | 1131 | T > C | Tyr > His | 0.33 (55/168)3 | 0.20 (54/274) |
| Exon 3 | 119 | G > A | Silent (Lys) | 0.13 (25/188) | 0.16 (16/100) |
| Exon 4 | 1391 | A > G | His > Arg | 0.18 (30/168)3 | 0.31 (89/286) |
| Exon 4 | 149 | C > T | Silent (Gly) | 0.01 (2/166) | 0.01 (1/100) |
| Exon 4 | 195 | T > C | Ser > Pro | 0.006 (1/168) | 0.01 (1/102) |
| Intron 4 | +341 | G > A | 0.09 (15/168) 3 | 0.02 (2/102) | |
| Exon 6 | 284 | C > T | Silent (Pro) | 0.08 (11/146) | 0.08 (9/108) |
| Exon 8 | 357 | T > C | Silent (Asn) | 0.11 (18/168) | 0.14 (20/142) |
| Exon 8 | 382 | G > T | Trp > Leu | 0.006 (1/168) | 0.01 (1/100) |
| Exon 9 | 450 | G > C | Silent (Ser) | 0.06 (10/168)3 | 0.00 (0/100) |
1
Previously reported polymorphisms
2
Sample size (number of alleles detected/number of alleles screened).
3
Allelic frequencies were significantly different between African American and Caucasian controls (p < 0.05).