Table 2b.
correlation and connectivity analyses: Fibromyalgia patients
| Region | Cluster size (# of voxels) | R values | z-score (peak value) | Coordinates (MNI) | ||
|---|---|---|---|---|---|---|
| x | y | z | ||||
| Negative correlation between pain (%BR) and BOLD response (FM group) | ||||||
| R brainstem | 72* | −.87 | 4.59 | 12 | −28 | −18 |
| Positive correlation between anxiety scores (STPI A) and BOLD response (FM group) | ||||||
| R inferior frontal gyrus/insula/medial frontal gyrus | 2165 | .86 | 4.39 | 50 | 26 | 12 |
| R superior frontal gyrus | 113 | .75 | 3.49 | 14 | 30 | 56 |
| R putamen | 230 | .82 | 4.01 | 24 | −4 | 2 |
| L superior temporal gyrus | 415 | .83 | 4.15 | −44 | −24 | −2 |
| L superior frontal gyrus | 123 | .80 | 3.85 | −12 | −10 | 70 |
| L middle frontal gyrus | 100 | .80 | 3.84 | −36 | 40 | −8 |
| L middle/inferior frontal gyrus | 302 | .77 | 3.63 | −34 | 28 | 22 |
| L putamen | 165 | .77 | 3.58 | −26 | −10 | −12 |
| Negative correlation between anxiety scores (STPI A) and BOLD response (FM group) | ||||||
| R/L rectus gyrus | 114 | −.76 | 3.55 | 0 | 50 | −20 |
| R/L superior frontal gyrus | 234 | −.85 | 4.33 | −2 | 60 | 36 |
| R temporal inferior gyrus/fusiform gyrus | 134 | −.62 | 3.94 | 50 | −38 | −26 |
| Positive correlation between MFI scores and BOLD response (FM group) | ||||||
| L insula/putamen | 187 | .74 | 3.36 | −38 | 10 | −6 |
| Negative correlation between MFI scores and BOLD response (FM group) | ||||||
| R temporal inferior gyrus/fusiform gyrus | 116 | −.76 | 3.54 | 52 | 40 | −24 |
| R orbitofrontal cortex/middle frontal gyrus | 138 | −.83 | 4.08 | 24 | 38 | −18 |
| L cerebellum, anterior lobe | 110 | −.75 | 3.48 | −20 | −44 | −30 |
| fc analysis – fc during inhibition between right inferior temporal/fusiform gyrus (SR) and TR: FM > HC | ||||||
| TR: R/L superior/medial frontal gyrus | 4.08 | / | 128 | 4 | 34 | 36 |
| TR: L supplementary motor area/superior frontal gyrus | 3.76 | / | 135 | −10 | 16 | 54 |
%BR = percentage body regions in pain, fc = functional connectivity, FM = fibromyalgia, HC = healthy controls, SR = seed region, TR = target region, L = left, R = right
Cluster fell slightly short of the apriori determined cluster extent of 92 voxels.