Figure 5. Fgfr1 genotype does not alter sociability.

Sociability testing before and after tamoxifen administration to induce conditional Fgfr1 gene deletion. Values show the time spent exploring the quadrant with a second mouse present. The Plp/CreERT:Fgfr1^fl/fl mice that were not fed cuprizone (white bars) are similar across testing periods. Plp/CreERT:Fgfr1^fl/fl mice (black bars) and Fgfr1^fl/fl mice (gray bars) both show a significant increase in sociability with acute cuprizone treatment (*p < 0.05, with vs. without cuprizone) prior to tamoxifen, which is therefore due to cuprizone and not due to Fgfr1 knockdown. Correspondingly, values before and after tamoxifen are similar between Plp/CreERT:Fgfr1^fl/fl (black bars) and Fgfr1^fl/fl (gray bars).