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. Author manuscript; available in PMC: 2014 Jun 20.
Published in final edited form as: Chem Biol. 2013 Jun 20;20(6):753–763. doi: 10.1016/j.chembiol.2013.05.008

Figure 5.

Figure 5

Other members of the kalihinol family also show copper chelating activity. a. Chemical structure of kalihinol analogs. b. 7 hpf embryos were treated with either 25 μg/ml or 2.5 μg/ml of kalihinol analogs and DMSO vehicle control (first, second, third columns). For phenotype rescue experiments, 5 hpf embryos were treated with kalihinols and given CuCl2 at 7 hpf (fourth, fifth, sixth columns). Embryos were monitored for wavy notochord (black arrow), loss of pigmentation (blue arrow) and hematopoeisis (red arrow). c. Effects of addition of Cu2+ to the 1H NMR linewidths of the methyl signal region of pulcherrimol.