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RECIST response rates in TRIA mice versus human melanoma
| Regimen | Mean day 0 tumor volume (mm3) |
Mean day 21 tumor volume (mm3) |
RECIST response rate (CR + PR + SD) |
Reported human response rates for melanoma |
|---|---|---|---|---|
| Untreated | 83 | 322 | 0% | |
| Carboplatin | 89 | 217 | 21% | 14%–23% |
| Paclitaxel | 62 | 182 | 21% | 14–18% |
| Carboplatin/paclitaxel | 41 | 97 | 38% | 19%–47% |
| Temozolomide | 88 | 266 | 10% | 15% (10%–17%) |
| Sunitinib | 63 | 115 | 32% | 33% |
| AZD6244/BEZ235 | 53 | 29 | 63% | Unknown |
