Table 1. Calculated disorder measures of the different functional groups and the three vesicle trafficking systems for human (H) and yeast (Y).
Number of proteins | Disordered residues (%) | Residues in DBRs (%) | Residues in LDRs (%) (k = 30 residues) | |||||
mean/median | mean/median | mean/median | ||||||
Functional groups | H | Y | H | Y | H | Y | H | Y |
COAT | 10 | 7 | 22.76/9.20 | 19.50/7.58 | 15.35/6.06 | 11.01/4.00 | 18.06/4.67 | 14.51/5.08 |
ASP | 64 | 38 | 25.17/21.49 | 25.20/15.80 | 14.80/8.93 | 13.85/8.22 | 17.28/8.13 | 18.16/8.54 |
EARP | 18 | 9 | 24.88/22.84 | 20.59/10.68 | 15.49/14.95 | 10.77/4.02 | 16.64/14.37 | 14.30/0 |
UCP | 32 | 32 | 16.77/6.95 | 14.11/5.53 | 9.35/0.96 | 5.83/0 | 7.29/0 | 7.86/0 |
MSTC | 44 | 42 | 6.01/4.75 | 8.96/5.08 | 2.39/0.74 | 3.58/0.74 | 1.94/0 | 4.12/0 |
OFRP | 19 | 16 | 17.82/12.86 | 10.74/7.88 | 7.89/5.93 | 3.67/1.65 | 8.12/0 | 4.44/0 |
SNARE | 37 | 24 | 23.74/18.26 | 26.97/24.63 | 9.31/6.91 | 13.58/11.51 | 5.72/0 | 8.93/0 |
NTSR | 25 | - | 31.74/19.43 | - | 14.79/8.44 | - | 20.75/8.65 | - |
Pathways | ||||||||
Clatrhin | 71 | 38 | 27.98/23.33 | 27.84/22.58 | 17.19/11.58 | 15.58/11.50 | 19.40/13.35 | 20.30/10.41 |
COPI | 22 | 16 | 13.33/6.90 | 13.92/8.22 | 6.11/0.83 | 6.28/0.95 | 6.80/0 | 8.13/0 |
COPII | 31 | 32 | 17.52/6.78 | 14.07/6.25 | 10.45/2.88 | 2.88/6.08 | 9.42/0 | 8.45/0 |
The functional groups are COAT (coat associated proteins), ASP (adaptors and sorting proteins), EARP (enzymatic activity related proteins), UCP (unclassified proteins), MSTC (multisubunit tethering complexes), OFRP (other fusion regulatory proteins), SNARE (SNARE proteins) and NTSR (neurotransmitter transport specific regulators). H stands for human, while Y indicates yeast data in the given column.