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. 2013 Jul 18;9(7):e1003121. doi: 10.1371/journal.pcbi.1003121

Figure 3. Example section of the models phase diagram showing all the possible phases: The phase space is four dimensional.

Figure 3

This section corresponds to fixing Sir2 deacetylase activity (Inline graphic) and Sir cooperative binding rates Inline graphic and varying the Sas2 activity (Inline graphic) and cooperative Dot1 activity (Inline graphic). Red diamonds represent region where silenced state is stable, green stars where active state is stable, magenta circles where bivalent state is stable, blue crosses where intermediate state is stable, and regions of overlap of symbols are bistable regions. The bistable solutions merge on Inline graphic line to a single solution.