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. 2013 Jul 18;9(7):e1003652. doi: 10.1371/journal.pgen.1003652

Figure 4. PDGFRβ is upstream of TCF21 at rs12190287 in HCASMC.

Figure 4

(a) TaqMan based qRT-PCR results showing relative mRNA expression levels of total TCF21 in heterozygous HCASMC treated with TGF-β1, PDGF-BB or PMA for indicated times. Expression levels were normalized to 18S and expressed as fold change from 0 h. *P<0.0001 versus 0 h. (b) TaqMan qRT-PCR expression results of c-JUN, JUND, and ATF3 in heterozygous HCASMC treated TGF-β1 or PDGF-BB for the indicated times. (c) Allele-specific TaqMan qRT-PCR based expression of TCF21 at rs12190287 shown as normalized allelic ratio C/G in heterozygous HCASMC treated with either TGF-β1 or PDGF-BB for the indicated times. *P<0.01 versus 0 h. Values are mean ± SD of triplicates. Similar results were observed from three independent experiments.