Table 2. Genotype and allele distribution of MTHFR SNPs in cases and controls.
| SNP | Genotype | ControlN (%) | CasesN (%) | 11vs12 | 11vs22 | 11vs(12+22) | 22vs12 | 22vs(12+11) | 11vs12vs22 | 1vs2 |
| 203G>A (rs2066472) | GG(11) | 201(100) | 618 (99.19) | P = 0.58 | P = 1.00 | P = 0.34 | P = 1.0 | P = 1.0 | P = 0.45 | – |
| GA(12) | 0 (0) | 3 (0.48) | ||||||||
| AA(22) | 0 (0) | 2 (0.32) | ||||||||
| G(1) | 402(100) | 1239(99.44) | ||||||||
| A(2) | 0 (0) | 7(0.56) | ||||||||
| 1298A>C (rs1801131) | AA(11) | 27(19.85) | 165(27.0) | OR = 0.71(CI = 0.44–1.14)P = 0.16 | 0.59(0.34–1.02)0.06 | 0.67(0.42–1.06)0.08 | 1.20(0.76–1.89)0.43 | 1.33(0.87–2.05)0.18 | 0.16 | 0.78(0.60–1.02)0.07 |
| AC(12) | 74(54.41) | 320(52.37) | ||||||||
| CC(22) | 35(25.73) | 126(20.62) | ||||||||
| A(1) | 128(47.05) | 650(53.19) | ||||||||
| C(2) | 144(52.95) | 572(46.81) | ||||||||
| 1793G>A (CM056008 NOIATAUM_DMCH) | GG(11) | 110(63.58) | 293(78.55) | 0.46(0.30–0.69)0.000 | 0.64(0.25–1.68)0.36 | 0.48(0.32–0.71)0.000 | 0.71(0.26–1.92)0.50 | 1.27(0.49–3.28)0.62 | 0.0008 | 0.55(0.39–0.78)0.000 |
| GA(12) | 56(32.37) | 68(18.23) | ||||||||
| AA(22) | 7(4.05) | 12(3.22) | ||||||||
| G(1) | 276(79.77) | 654(87.67) | ||||||||
| A(2) | 70(20.23) | 92(12.33) | ||||||||
| Intronic (rs3818762) | CC(11) | 52(30.41) | 137(35.86) | 0.78(0.52–1.18)0.25 | 0.78(0.47–1.29)0.33 | 0.78(0.53–1.15)0.21 | 1.00(0.63–1.61)1.0 | 1.11(0.71–1.73)0.64 | 0.45 | 0.86(0.67–1.12)0.26 |
| CG(12) | 82(47.95) | 169(44.24) | ||||||||
| GG(22) | 37(21.64) | 76(19.90) | ||||||||
| C(1) | 186(54.39) | 443(57.98) | ||||||||
| G(2) | 156(45.61) | 321(42.02) |