Table 4. Genotype and allele distribution of MTHFR SNPs in relation to sperm count.
| SNP/rsID | Genotype | Count <20 M/ml | Count >20 M/ml and <100 M/ml | Count>100 M/ml | 11vs12 | 11vs22 | 11vs(12+22) | 22vs12 | 22vs(12+11) | 11vs12vs22 | 1vs2 |
| 203G>A (rs2066472) | GG(11) | 100(100) | 273(100) | 185(98.40) | P = 0.37 | 0.14 | 0.05 | 1.0 | 0.14 | 0.20 | 0.007* |
| GA(12) | 0(0) | 0(0) | 1(0.53) | ||||||||
| AA(22) | 0(0) | 0(0) | 2(1.06) | ||||||||
| G(1) | 200(100) | 546(100) | 371(98.67) | ||||||||
| A(2) | 0(0) | 0(0) | 5(1.33) | ||||||||
| 1298A>C (rs1801131) | AA(11) | 15(18.07) | 44(29.33) | 54(25.47) | 0.15 | 0.4 | 0.17 | 0.66 | 0.73 | 0.35 | 0.41 |
| AC(12) | 50(60.24) | 75(50.0) | 107(50.47) | ||||||||
| CC(22) | 18(21.69) | 31(20.67) | 51(24.06) | ||||||||
| A(1) | 80(48.19) | 163(54.33) | 215(50.71) | ||||||||
| C(2) | 86(51.81) | 137(45.67) | 209(49.29) | ||||||||
| 1793G>A (CM056008 NOIATAUM_DMCH) | GG(11) | 29(70.73) | 56(74.67) | 103(78.63) | 0.46 | 0.51 | 0.55 | 0.43 | 0.50 | 0.57 | 0.53 |
| GA(12) | 9(21.95) | 17(22.67) | 21(16.03) | ||||||||
| AA(22) | 3(7.32) | 2(2.67) | 7(5.34) | ||||||||
| G(1) | 67(81.71) | 129(86.0) | 227(86.64) | ||||||||
| A(2) | 15(18.29) | 21(14.0) | 35(13.36) | ||||||||
| Intronic (rs3818762) | CC(11) | 13(30.95) | 31(38.75) | 46(34.07) | 0.89 | 0.45 | 0.75 | 0.67 | 0.50 | 0.80 | 0.4 |
| CG(12) | 17(40.48) | 33(41.25) | 54(40.0) | ||||||||
| GG(22) | 12(28.57) | 16(20.0) | 35(25.93) | ||||||||
| C(1) | 43(51.19) | 95(59.38) | 146(54.07) | ||||||||
| G(2) | 41(48.81) | 65(40.63) | 124(45.93) |