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. 2013 Jul 18;8(7):e67551. doi: 10.1371/journal.pone.0067551

Figure 4. Sensitivity of DmNa v9-1 to deltamethrin is modulated by co-expression of TEH1.

Figure 4

(A) A representative tail current induced by 1 µM deltamethrin. (B) Percentage of channel modification by deltamethrin (multiple-pulse test). Tail currents were elicited by a 66.7-Hz train of 100 5-ms depolarization from -120 to 0 mV. (C) Co-expression of TEH1 significantly reduced the stability of DmNav9-1 peak sodium current under repeated conditioning depolarizations. Sodium currents were recorded during 20-ms step depolarizations from -120 mV to -10 mV after 0-100 conditioning pulses (5-ms pulses from -120 mV to 0 mV at 66.7 Hz). (D) Percentage of channel modification by deltamethrin (single-pulse test). Tail currents were elicited by a 500 ms depolarization from -120 mV to 0 mV. All data are shown as mean ± SEM for 9-15 oocytes. * indicates significant difference compared to the DmNav9-1 channel using one-way ANOVA with Scheffe’s post hoc analysis (p<0.05).