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. 2013 Jul 18;8(7):e68943. doi: 10.1371/journal.pone.0068943

Figure 5. Egr-1 activation by silica was mainly dependent upon activation of the MAPKs pathway.

Figure 5

(a) The effects of Egr-1 nuclear protein expression after administration of kinase inhibitor was determined by western-blot (5B、5C). The Egr-1 expression at nuclear protein and mRNA level was inhibited by U0126 and SB230580 respectively, but not completely disappeared by combination of both; The expression of Egr-1 was not changed by pretreatment with H7, a PKC inhibitor. The significance of Egr-1 expression is noted as P<0.05 (*), P<0.01(**).