Skip to main content
. 2013 Jul 18;8(7):e68694. doi: 10.1371/journal.pone.0068694

Figure 8. Exogenous S100A8/A9 proteins amplify VILI via Toll-like receptor 4.

Figure 8

Total protein (A), immunoglobulin M (IgM) (B) Neutrophil influx (C), interleukin (IL)-6 (D), keratinocyt-derived chemokine (KC) (E), macrophage inflammatory protein (MIP)-2 (F), IL-1β (G) and tumor necrosis factor (TNF)-α concentrations (H) in C3H-HeN and C3H-HeJ mice exposed to S100A8/A9 (30 µg/mouse) or vehicle intratracheally at start of high tidal volume mechanical ventilation. Mice were ventilated for 5 hours. Data represent mean (SEM) of 7–8 mice per group. *p<0.05, **p<0.01, ***p<0.001 versus vehicle treated mice. #p<0.05 S100A8 versus S100A8/A9 treated mice.