Skip to main content
. Author manuscript; available in PMC: 2013 Jul 18.
Published in final edited form as: Antivir Ther. 2012 Sep 28;17(7):1233–1242. doi: 10.3851/IMP2411

Table 1.

Published in vitro EC50 acute infection values for various ARV drugs in primary macrophage cell cultures and the calculated ME scores

ARV drug Acute infection in macrophages EC50, nM ME scorea
NRTI
Abacavir sulfate 300 3
Didanosine 50 20
Emtricitabineb 80 12.5
Lamivudine 20 50
Stavudine 240 4
Tenofovir disoproxil fumarate 20 50
Zalcitabine 3 333
Zidovudine 20 50
NNRTI
Delavirdine 10 100
Efavirenz 10 100
Nevirapine 50 20
Protease inhibitor
Amprenavirc 10 100
Indinavir 60 17
Nelfinavir 80 12.5
Ritonavir 120 8.3
Saquinavir 50 20
Fusion inhibitor
Enfuvirtide 20 50
a

(1/median effective concentration [EC50])×1,000.

b

Unpublished data from the laboratory of RFS.

c

Amprenavir values used as an surrogate for fosamprenavir, a prodrug of amprenavir. Adapted with permission from [18].

ARV, antiretroviral; ME, monocyte efficacy; NNRTI, non-nucleoside reverse transcriptase inhibitor; NRTI, nucleoside reverse transcriptase inhibitor.