Table 3.
Summary of unadjusted index SNP and strongest single locus associations with UFs among the Right from the Start and BioVU cohorts
| Population | Gene | rs # | MA | MAF |
OR | 95% CI |
P | ||
|---|---|---|---|---|---|---|---|---|---|
| No UFs | UF | Lower | Upper | ||||||
| RFTS EA1 | Nearby SLK | rs11191875 | T | 0.02 | 0.05 | 2.78 | 1.24 | 6.26 | 0.014 |
| rs7913069* | T | 0.01 | 0.01 | 0.42 | 0.05 | 3.20 | 0.400 | ||
| BET1L | rs939917 | T | 0.34 | 0.50 | 1.86 | 1.12 | 3.07 | 0.016 | |
| rs2280543* | T | 0.04 | 0.02 | 0.55 | 0.20 | 1.56 | 0.262 | ||
| TNRC6B | rs11089974 | T | 0.20 | 0.26 | 1.46 | 1.01 | 2.10 | 0.046 | |
| rs12484776* | G | 0.20 | 0.27 | 1.48 | 1.03 | 2.13 | 0.035 | ||
| rs4821942 | A | 0.20 | 0.28 | 1.52 | 1.06 | 2.18 | 0.024 | ||
| BioVU EA | |||||||||
| Nearby SLK | rs7913069* | T | 0.01 | 0.02 | 1.18 | 0.71 | 1.97 | 0.527 | |
| BET1L | rs2280543* | T | 0.05 | 0.04 | 0.68 | 0.51 | 0.92 | 0.013 | |
| TNRC6B | rs12484776* | G | 0.20 | 0.23 | 1.17 | 1.00 | 1.36 | 0.050 | |
1
European Americans are all non-Hispanic
MA = major allele, MAF = minor allele frequency, OR = odds ratio, CI = confidence interval
*
Index SNP from previous GWAS
Highlighted results indicate p ≤ 0.05