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. Author manuscript; available in PMC: 2014 Jul 15.
Published in final edited form as: Cancer Res. 2013 May 30;73(14):4395–4405. doi: 10.1158/0008-5472.CAN-12-3765

Fig.5.

Fig.5

OHT triggers EGFR degradation. (A) Whole cell lysates from OHT-treated cells demonstrated a time-dependent decrease in EGFR levels in the presence of the protein synthesis inhibitor CHX (100μM, 1hr pre-treatment). (B) MPNST, (C, D and E) glioma and (F) breast cancer cell lines demonstrated a concentration-dependent decrease in EGFR levels following OHT treatment (48 hours).