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. Author manuscript; available in PMC: 2014 Dec 1.
Published in final edited form as: J Neuroimmune Pharmacol. 2013 Mar 19;8(5):10.1007/s11481-013-9446-8. doi: 10.1007/s11481-013-9446-8

Figure 6. MiR-9 mediates downregulation of KCNMA1 3′UTR v.1-5 but not 3′UTR for v.2-3-4-6 in SH-SY5Y cells exposed to HIV and MA.

Figure 6

Incubation of differentiated SH-SY5Y cells with HIV and MA caused a decrease in expression of KCNMA variants containing the 3′UTR(a) (A), and for 3′UTR(b) (B). Pre-incubation with Mercury LNA inhibitor specific to miR-9 stopped KCNMA1 mRNA downregulation. Black bars - cells pre-incubated with scrambled LNA sequence, grey bars - cells pre-incubated with anti-miR-9 LNA sequence. Comparisons noted in (A) P = 0.07; and for comparisons noted in (B) P < 0.01 by Student’s t test.