Table 2.

Comparison of data on Parkin/PINK1-dependent mitophagy in neurons.

	Cai et al. (76)	Joselin et al. (77)	Seibler et al. (78)	Van Laar et al. (79)	Rakovic et al. (80)
Neuronal type	Cortical	Cortical	IPS-derived dopaminergic neurons	Cortical	IPS-derived dopaminergic neurons
Glial bed	Yes	No	No	No	No
Days in vitro	8–10	8	–	9	–
Apoptotic inhibitors	Z-VAD-FMK	No	No	No	No
B-27	Yes	No	–	Yes	Yes
Uncoupling agent + time of exposure	10 μM CCCP 24 h	5 μM CCCP 4 h	1 μM Valinomycin 12 h	10 μM CCCP 6 h	1 μM Valinomycin 12 h
% Cells with parkin recruitment	30%	70%	N/A (increased colocalization)	No CCCP effect 25% basal	N/A
Quantified parkin-dependent mitophagy	No	No	No (reduced mtDNA copy numbers)	N/A	Yes (no parkin-dependent mitophagy)
Endogenous parkin recruitment	Yes	N/A	N/A	No	N/A
PINK1 dependence	N/A	Yes	Yes	N/A	Yes