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Comparison of parkin recruitment in immortalized cells versus neurons.
| Immortalized Cells (HeLa, Hek293T, SH-SY5Y, MEFs) | Neurons (primary, IPS-derived) | |
|---|---|---|
| Mean time of parkin recruitment upon ΔΨm depolarization (more than 30% cell with parkin on mitochondria) | 30 min (50) | 4 h (77); 6 h (79); 12 h (78); 24 h (76) |
| Dependence on PINK1 | Yes | Yes |
| Survival after long-term exposure to chemical uncouplers | Yes | N/A; use of apoptotic inhibitors (76) |
| Complete removal of mitochondria | Yes | N/A |
