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Effect of carboplatin on therapeutic efficacy of 213Bi-trastuzumab. Athymic mice bearing i.p. LS-174T xenografts were injected i.p. with carboplatin 24 hours after the injection of 500 μCi (i.p.) 213Bi-labeled trastuzumab (◊). Another set of mice were injected with 213Bi-HuIgG as a nonspecific control, followed by carboplatin 24 hours later (◯). Additional groups were untreated (●), carboplatin (▽), 213Bi-trastuzumab (■), and 213Bi-HuIgG (▴).
