FIG. 3.

Efficacy of multiple doses of carboplatin in combination with a single administration of ²¹³Bi-trastuzumab. Athymic mice bearing i.p. LS-174T xenografts were injected i.p. with carboplatin 24 hours after the injection of 500 μCi (i.p.) ²¹³Bi-labeled trastuzumab (◊), which was then followed by 2 additional doses of carboplatin at 1-week intervals (▽). Another set of mice were injected with ²¹³Bi-HuIgG as a nonspecific control, followed by the same dosing with carboplatin (□). Additional groups were untreated (●), 3 doses of carboplatin (◯), ²¹³Bi-trastuzumab (▼), and ²¹³Bi-HuIgG (■).