Table 2.
Associations Between Hepatitis C Virus, Inflammatory Cytokines, and Absence of Liver Fibrosis Among HIV-Infected Persons with a History of Alcohol Problems
| Model IaOR (95% CI) | Model IIaOR (95% CI) | Model IIIaOR (95% CI) | Model IVaOR (95% CI) | Model VaOR (95% CI) | |
|---|---|---|---|---|---|
| HCV | 0.32 (0.17, 0.57) | 0.37 (0.19, 0.71) | 0.33 (0.17, 0.63) | 0.43 (0.22, 0.86) | 0.47 (0.23, 0.96) |
| Age | 0.89 (0.85, 0.93) | 0.88 (0.84, 0.93) | 0.88 (0.84, 0.93) | 0.90 (0.85, 0.95) | 0.89 (0.84, 0.94) |
| Gender | |||||
| Female | 1.13 (0.56, 2.30) | 1.11 (0.49, 2.54) | 1.10 (0.48, 2.55) | 1.22 (0.52, 2.87) | 1.25 (0.52, 2.99) |
| Male | 1 | 1 | 1 | 1 | 1 |
| CD4 count | |||||
| <200 | 0.45 (0.19, 1.07) | 0.63 (0.24, 1.63) | 0.63 (0.24, 1.66) | 0.63 (0.22, 1.81) | 0.69 (0.24, 2.04) |
| 200–500 | 0.50 (0.25, 0.98) | 0.64 (0.31, 1.33) | 0.62 (0.30, 1.28) | 0.71 (0.33, 1.51) | 0.76 (0.35, 1.64) |
| >500 | 1 | 1 | 1 | 1 | 1 |
| HIV RNA | |||||
| ≤500 | 1.36 (0.67, 2.78) | 1.32 (0.60, 2.87) | 1.29 (0.59, 2.81) | 1.44 (0.64, 3.25) | 1.34 (0.58, 3.09) |
| >500 | 1 | 1 | 1 | 1 | 1 |
| Antiretroviral therapy | 1.49 (0.75, 2.99) | 1.45 (0.67, 3.14) | 1.43 (0.67, 3.04) | 1.51 (0.68, 3.32) | 1.48 (0.65, 3.35) |
| BMI | 1.05 (0.98, 1.13) | 1.09 (1.01, 1.18) | 1.09 (1.01, 1.18) | 1.07 (0.99, 1,.16) | 1.08 (0.99, 1.17) |
| IL-10 | |||||
| 1st tertile | 1 | 1 | |||
| 2nd tertile | 0.65 (0.29, 1.49) | 0.66 (0.27, 1.63) | |||
| 3rd tertile | 0.47 (0.20, 1.08) | 0.58 (0.22, 1.53) | |||
| TNF-α | |||||
| 1st tertile | 1 | 1 | |||
| 2nd tertile | 0.80 (0.36, 1.75) | 0.81 (0.34, 1.90) | |||
| 3rd tertile | 0.46 (0.21, 1.02) | 0.69 (0.27, 1.76) | |||
| IL-6 | b | ||||
| 1st tertile | 1 | 1 | |||
| 2nd tertile | 1.09 (0.47, 2.56) | 1.24 (0.51, 3.00) | |||
| 3rd tertile | 0.43 (0.19, 0.98) | 0.54 (0.23, 1.29) | |||
a
Adjusted for age, gender, CD4 count, HIV RNA, current antiretroviral therapy, and BMI.
b
Global p-value <0.05.
OR (95% CI), odds ratio (95% confidence interval); BMI, body mass index.