Figure 2. Increased recruitment of inflammatory cells in ESE-1^−/− mice in response to Ang II. (a,c) Immunohistochemical staining and (b,d) quantitative analysis of infiltration of CD3(T cells, original magnification ×250) and Mac-3 (macrophages, original magnification ×400) in the adventitia of thoracic aorta of ESE-1^+/+ vs. ESE-1^−/− mice after infusion of Ang II (1.4mg/kg/day) for 1 week. *P < 0.01 ESE-1^−/− vs. ESE-1^+/+. Values represent mean ± s.e.m., n = 5. Ang II, angiotensin II; ESE-1, epithelium-specific ETS transcription factor-1; IgG, immunoglobulin G.