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. 2013 Jun 3;15(12):3118–3121. doi: 10.1021/ol401327r

Table 1. Model Studies of C29 Reduction.

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entry conditions yield (%) dr
1 NaBH4, MeOH, rt 55 2:1
2 l-selectride, THF, –78 °C –a –
3 LiAlH(Ot-Bu)3, THF, −10 °C → rt –a –
4 NaBH4, CeCl3·7H2O, MeOH, 0 °C 34 7:1
5 Zn(BH4)2, Et2O, 0 °C 77 10:1
a

Slow reaction rate, forming predominantly elimination and decomposition products.