Figure 9.

Chronic, but not acute, D1DR stimulation decreases NMDAR-mediated currents. A, B, Time course of whole-cell responses to NMDA (100 μm) before and after pretreatment with SKF38393 in saline controls and cocaine-experienced animals. C, Summary histograms of whole-cell NMDA responses expressed as current density (t₍₃₂₎ = 2.1; *p < 0.05 vs nontreated saline; n = 17–25 cells). D, A summary of eEPSCs (Evoked) and whole-cell NMDAR responses during acute application of SKF38393. In the majority of cells, NMDAR-mediated currents are potentiated during SKF38393 application.