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. Author manuscript; available in PMC: 2013 Jul 19.
Published in final edited form as: Stereotact Funct Neurosurg. 2013 Jan 22;91(2):69–78. doi: 10.1159/000342492

Figure 1.

Figure 1

Illustration of overflow loss. A: Correlation between the distance of the catheter tip to the nearest putamen boundary and the fraction of measured gadolinium outside the putamen after 30 μl of infusion for 10 infusions dominated by overflow. B–D: Quantitative T1 maps (negated) for a specific example (Cy0298-left) centered at the catheter tip during the infusion of 100μl (infusion rate: 1μl/min), show infusate overflow out of the putamen over time. B: 6 mm of backflow contained within the putamen was detected a few minutes after the start of the infusion. C: At 32 minutes infusate begins to move past the medial edge of the putamen. D: At the end of the 100-minute infusion the tracer begins to spread into the external capsule on the lateral side of the putamen (arrows). E: Plots of the computed amount of tracer outside the putamen divided by the total measured amount at approximately 10 minute intervals (Cy0298).