Table 1.
Infusate distribution measurements for all 22 infusions. ‘Cath.’ refers to the catheter tip type:VT, valve tip (stylet end port); VT*, valve tip, occluded before retrieval; NS, no stylet end port; FM = fiber mesh. Side: r, right; l, left. Depth refers to the length of catheter inside the putamen. Tip dist. is the distance to from the catheter tip to the nearest putamen boundary. Backflow is the extent of tracer reflux visible along the catheter shaft visible 10 minutes after the start of the infusion. Withdrawal refers to the time end of infusion and removal of the catheter. Loss fractions (perivascular, backflow, and total) are the fraction of the total measured amounts of infusate that are outside the putamen
| Loss Fraction @ 30μl | Loss Fraction @ 100μl | ||||||||||
|---|---|---|---|---|---|---|---|---|---|---|---|
| Animal | Side | Cath. | Depth (mm) |
Tip dist. (mm) |
Backflow (mm) |
Withdrawal (min) |
Perivascular | Backflow | Overall | Backflow | Overall |
| R91070 | r | VT | 5.0 | 2.5 | 5.0 | 10 | 16% | 39% | 66% | ||
| R95106 | r | VT | 6.0 | 2.5 | 2.0 | 12 | 3% | 6% | 24% | ||
| R03044 | r | VT | 6.5 | 2.5 | 4.0 | 13 | 8% | 11% | 30% | ||
| R03044 | l | VT | 6.5 | 2.0 | 4.0 | 13 | 7% | 22% | 38% | ||
| R03064 | r | VT | 8.0 | 1.0 | 3.0 | 12 | 6% | 13% | 37% | ||
| R03064 | l | VT | 5.0 | 2.0 | 3.0 | 12 | 2% | 9% | 34% | ||
| Cy0140 | l | VT | 6.0 | 2.5 | 13.0 | 12 | 1% | 62% | 67% | 70% | 76% |
| Cy0286 | l | VT | 4.5 | 0.5 | 3.0 | 16 | 20% | 34% | 52% | ||
| Cy0287 | r | VT | 7.0 | 1.5 | 3.0 | 19 | 14% | 18% | 40% | ||
| Cy0288 | r | VT | 5.5 | 0.5 | 3.5 | 16 | 0% | 23% | 40% | ||
| Cy0295 | r | VT | 5.0 | 1.5 | 8.0 | 17 | 0% | 7% | 14% | 43% | 51% |
| Cy0298 | l | VT | 7.0 | 2.0 | 6.0 | 13 | 0% | 5% | 24% | ||
| Cy0299 | l | VT | 6.5 | 0.5 | 5.0 | 12 | 8% | 33% | 56% | ||
| Cy0279 | l | VT* | 7.0 | 1.5 | 5.0 | 16 | 0% | 13% | 46% | ||
| R05008 | r | NS | 7.0 | 2.0 | 16.0 | 15 | 0% | 21% | 32% | 34% | 46% |
| Cy0286 | r | NS | 7.0 | 0.7 | 3.5 | 14 | 20% | 42% | 52% | ||
| Cy0287 | l | NS | 9.0 | 1.5 | 3.0 | 18 | 35% | 41% | 56% | ||
| Cy0288 | l | NS | 4.5 | 2.0 | 6.0 | 17 | 0% | 8% | 20% | 29% | 49% |
| Cy0295 | l | NS | 5.0 | 1.5 | 3.0 | 21 | 31% | 33% | 51% | ||
| Cy0298 | r | FM | 6.0 | 1.8 | 4.0 | 30 | 0% | 3% | 21% | ||
| Cy0299 | r | FM | 5.5 | 1.5 | 3.5 | 13 | 25% | 30% | 47% | ||
| Cy0279 | r | FM | 6.0 | 1.0 | 4.0 | 12 | 11% | 13% | 40% | ||
|
| |||||||||||
| Mean ± SD | 6.2 ± 1.1 | 1.6 ± 0.7 | 5 ± 3.4 | 9.4% ± 10.9 | 24% ± 16 | 44% ± 13 | |||||