Table 1.
Clinical characteristics of 14 CF patients colonized with Achromobacter species
| Characteristic(s) (n = 14) | Colonization result for characteristic |
|
|---|---|---|
| Chronic (n = 9) | Sporadic (n = 5) | |
| Mean ± SD age (yr) | 24.3 ± 14.5 | 10.9 ± 3 |
| No. female (%) | 6/9 (66.6) | 2/5 (40) |
| Body mass index (%) | 20.3 ± 4.7 | 16.8 ± 2.3 |
| No. (%) with CF transmembrane regulator mutation type: | ||
| F508del homozygote | 4/9 (44.4) | 2/5 (40) |
| F508del heterozygote | 3/9 (33.3) | 2/5 (40) |
| Others | 2/9 (22.2) | 1/5 (20) |
| No. (%) with: | ||
| Pancreatic insufficiency | 7/9 (77.7) | 5/5 (100) |
| Diabetes mellitus | 2/9 (22.2) | 2/5 (40) |
| Liver disease | 2/9 (22.2) | 0/5 (0) |
| Mean ± SD pulmonary function (%)a | ||
| FEV1 | 66.1 ± 15.9 | 61.8 ± 17.5 |
| FVC | 75.3 ± 15.6 | 69 ± 16.9 |
| No. (%) of patients hospitalized 1 yr before | 4/9 (44.4) | 1/5 (20) |
| No. (%) with antimicrobial exposure tob: | ||
| ≥3 groups | 4/9 (44.4) | 3/5 (60) |
| 1 or 2 groups | 5/9 (55.5) | 2/5 (40) |
| Tobramycin (inhaled) | 3/9 (33.3) | 2/5 (40) |
| Colistin (inhaled) | 2/9 (22.2) | 1/5 (20) |
| No. (%) coinfected with other microorganism(s) | ||
| Staphylococcus aureus | 5/9 (55.5) | 2/5 (40) |
| Pseudomonas aeruginosa | 4/9 (44.4) | 1/5 (20) |
| Burkholderia cepacia complex | 1/9 (11.1) | 0/5 (0) |
| Enterobacteriaceae | 0/9 (0) | 1/5 (20) |
| Other nonfermentative Gram-negative bacilli | 1/9 (11.1) | 2/5 (40) |
| Haemophilus influenzae | 2/9 (22.2) | 1/5 (20) |
a
FEV1, forced expiratory volume in 1 s; FVC, forced vital capacity.
b
Antimicrobial exposure in the previous year of acquisition and 1 year after the first isolate. The groups of antimicrobial agents were β-lactams, macrolides, fluoroquinolones, aminoglycosides, trimethoprim-sulfamethoxazole, and others.