Table 2.
Pharmacokinetic parameters obtained by noncompartmental analysis in patients after a 30-min intravenous infusion of 2 g of cefotaxime administered every 8 ha
| Patient | Vdss,u (liters) | CLss,u (liters/h) | t1/2 plasma (h) | t1/2 brain (h) | Brain ECF-free plasma AUC ratio |
|---|---|---|---|---|---|
| P1 | 51.4 | 29.2 | 2.0 | 2.9 | 0.278 |
| P2 | 40.0 | 27.4 | 2.1 | 3.3 | 0.119 |
| P3 | 55.0 | 33.7 | 1.7 | 0.7 | 0.154 |
| P4 | 88.6 | 68.2 | 1.5 | 1.9 | 0.383 |
| P5 | 42.5 | 36.1 | 1.6 | 2.0 | 0.369 |
| Mean | 55.5 | 38.9 | 1.8 | 2.2 | 0.261 |
| SD | 20.9 | 19.2 | 0.3 | 1.2 | 0.121 |
a
Individual and mean (±SD) results are presented.