Table 1.
Pharmacokinetic parameters for atorvastatina
| Form of atorvastatin | Tmax (h) | Cmax (ng/ml) | AUClast (ng · h/ml) | AUCinf (ng · h/ml) | t1/2 (h) | CL/F (liters/h) |
|---|---|---|---|---|---|---|
| Parent form | ||||||
| Atorvastatin alone (day 1, n = 10) | 2.25 (1.00–4.00) | 10.3 (43) | 93.2 (50) | 95.0 (49) | 8.81 (15) | 498 (40) |
| Atorvastatin + boceprevir (day 9, n = 10) | 4.00 (3.00–4.00) | 27.7 (50) | 212 (38) | 214 (38) | 6.73 (11) | 210 (34) |
| ortho-Hydroxy metabolite | ||||||
| Atorvastatin alone (day 1, n = 10) | 4.00 (1.50–6.00) | 7.08 (27) | 83.8 (46) | 86.5 (46) | 9.89 (12) | |
| Atorvastatin + boceprevir (day 9, n = 10) | 4.00 (3.00–8.00) | 2.59 (65) | 35.1 (60) | 40.8b (53) | 7.91b (20) | |
| para-Hydroxy metabolite | ||||||
| Atorvastatin alone (day 1, n = 10) | 8.00 (4.00–12.0) | 0.307 (55) | 8.09 (79) | |||
| Atorvastatin + boceprevir (day 9, n = 10) | 12.0 (3.00–12.0) | 0.702 (53) | 9.49 (64) |
a
All values are means with coefficients of variations in parentheses, except in the case of Tmaxs, which are medians with ranges in parentheses.
b
n = 8.