Table 3.
Replication capacities of recombinant HIV-1 determined by PhenoSense IN single-cycle infectivity assays
| Site-directed IN mutant virus | RC (% of WT)a |
|---|---|
| WT | 100 |
| T66A | 69 |
| T66I | 84 |
| T66K | 9 |
| E92G | 6 |
| E92Q | 64 |
| T97A | 68 |
| Y143C | 49 |
| Y143H | 78 |
| Y143R | 75 |
| S147G | 108 |
| Q148H | 54 |
| Q148K | 36 |
| Q148R | 70 |
| N155H | 72 |
| T66I + E92Q | 25 |
| T66I + Q148R | 20 |
| T66I + N155H | 16 |
| E92Q + Q148R | 4 |
| E92Q + N155H | 40 |
| Q148R + N155H | 15 |
a
Data shown represent the results of an independent experiment performed in the absence of drug by Monogram Biosciences (South San Francisco, CA). RC, replication capacity.