Table 3.

PK parameters for infected mice in the efficacy study^a

Dose group	Drug PK	Combination drug	Dose (mg/kg)	Regimenb	Cmaxc (μg/ml)	Tmaxd (h)	AUC (h · μg/ml)	Half-life (h)	%TMIC in 24 he
1	Amoxicillin	Clavulanate	200	BID, Q12	43.07	1.00	82.12	0.58	33
1	Clavulanate	Amoxicillin	50	BID, Q12	26.39	0.08	15.67	0.21	13
2	Meropenem	Clavulanate	300	TID, Q8	218.04	0.08	89.65	0.39	25
2	Clavulanate	Meropenem	75	TID, Q8	24.88	0.08	13.34	0.46	19

^aThe parameters were estimated after the 10th dose.

^bBID, twice a day; TID, three times a day; Q12, every 12 h; Q8, every 8 h.

^cC_max, maximum concentration of drug in plasma.

^dT_max, time to maximum concentration of drug in plasma.

^eBased on in vitro synergy between amoxicillin and clavulanate, a 1-μg/ml concentration was used for %T_MIC calculation for clavulanate. Amoxicillin, clavulanate, and meropenem are reported to be 80%, 75%, and 98% free in plasma, respectively (9, 18). Therefore, the %T_MIC values were almost the same for free plasma concentrations.