Fig 3.

Effect of MI-S topical treatment on ocular viral titers. Mice (n = 10) had their right corneas infected and treated as follows: group 1, infected, untreated; group 2, MI-S treatment at 1 mg/ml (11.69 μM), 5 times daily after infection for 10 days; group 4, vehicle (PBS) treatment, 5 times daily after infection, for 10 days. Tear film samples were collected, and titers were determined as described in Materials and Methods. Values are expressed as means ± SEM from 10 mice in each group. Statistical analysis (one-way ANOVA followed by the Dunn's multiple comparison test) demonstrated significant differences between group 1 and groups 2 and 4, on day 7 postinfection; *, P < 0.05.